Yes, there is a very real (and high) chance that it won't work. There's more information about tile limits and palette issues on the DA post if you want to read it. DPPt has more than 15 colours, so you'd have to edit it yourself to get it to work. If you're willing to play around with it, that's fine. Also, it worries me a bit that you have no idea about your regions' layout. More info, maybe?