I would have them make my 5 favourite Pokémon with over 500 HP and 500 base stats for all stats, and an Ability making every type's attack moves not very effective against them, as well as being immune to weather effects, status changes, stats debuffs, moves' secondary effects! No NPC would have any of them and we would have 5 Masterballs to catch them if encountered in the wild!
What if Pokémon ruled over humans ?