From this we can see Professor Oak looks like he has eaten a few cakes since last time and he looks older/different.
We can see in the second frame that Red and Blue are clashing this might signal that they travel together like Ash-Brock-Misty this would be very good to clear a few things up in the games like... How did Blue get past nugget Bridge without joining team rocket... How did Blue get into silph co. without a card key, well hopefully Blue and Red travel together bonding and becoming fierce rivals
In the third frame we can see Brock looking much older than 15 with 2 pokeballs in his hands this could mean that Brock may help the 2 boys in their quest or maybe he is picking some pokeballs to fight with.
In the 4th frame we can see a Geodude using Tackle on Charmander it is safe to assume this Charmander is Red's and that Geodude is Brocks. Why Brocks well in the frame before we can see Brock with 2 pokeballs hinting maybe at an upcoming gym battle.
In the 5th Frame we see lance putting his hands on Red's shoulders, leaving a few things to wonder.
Are they related. But we can all safely guess that this is when Red has defeated him and Lance is giving one of those friendship speeches that we all adore.
In the second last frame we can see a Blastoice this probably being the big fight between Champion Blue and Red not much else.
in the last frame we see Red yelling in what looks like a cave, what cave could this be? Rock Tunnel, Altering Cave could be any but why is Red yelling probably because he has lost his way or he is in a fight