I really hate to pick on you, and I'm sorry if I am, but what honestly did I just read...
For starters, it really sounds like you thought May and Dawn didn't care about Ash at all. Just because they have their own goals, it doesn't mean they can't still have meaningful friendships and care about each other; Ash is the exact same, isn't he? I find it odd you didn't even throw Misty and Iris in the same boat. Every girl has been to every one of his gym battles, and even Dawn went the extra mile to wear the fanservice-y cheerleader outfit on occasion.
To be fair regarding May, the way they handled her departure, one could make the case that May didn't even care for Ash at all, especially when she didn't seem even remotely sad, certainly not crying, or even hesitant. In fact, she seemed to want to get to Johto ASAP. The only one of the main cast of AG who was even remotely hesitant about leaving the group was Max. At least, that's what the episode review thread on SPPf for the split-up episode of AG indicated, as the posters basically mentioned that it went along the lines of May just saying goodbye and then departing, little indication that she was even sad or hesitant. Dawn at least actually cried a bit before leaving Ash. Heck, Misty did not take her departure well at all, so they at least showed they actually cared for Ash, being hesitant to actually leave. Come on, even Anakin Skywalker, who was excited about leaving Tatooine in Phantom Menace, also expressed some concern for his mom, and was devastated when he learned she can't come with.
Milk takes around three weeks to go sour. I find it odd that you think Serena is starting to go down the proverbial drain because she slapped his hand away once, when he was reaching for a small piece of cake that she envisioned would be split between the four of them(five, after Diantha showed up, and that was XY028).
Yeah, agreed with that. Then again, exempting possibly Ash, this guy has a notoriously low tolerance for even the slightest infraction of any of the main characters. He's got a lower tolerance rate than Sheldon Cooper from the Big Bang Theory, and that's saying a lot. He likes Serena, yet the very instant she does something even slightly violent, even if it was actually perfectly justified, it's all "darn you to hades" from him. Man, talk about fair-weather friends/fair-weather fans. Actually, maybe even less than that. I know Misty's flaws, heck, Ash's flaws, yet even I don't abandon them for even the slightest infraction, never mind any of the more severe ones they did.
And I guess Serena isn't allowed to have a goal, apparently, because that automatically means she's not going to care about Ash anymore? Is it wrong to have a goal of some sort that doesn't have to do with Ash? Who said they won't try to balance her crush subplot with a goal? Isn't that what people in real life do? If you haven't picked up, XY059 is called "Ash and Serena's First Date!? The Vow Tree and the Present!".
Yeah, and besides, she'd need to have a goal just to actually serve a purpose on the show. Even Misty had a goal, at least by Johto, maybe earlier. Even May and Dawn, who I'd argue are closer to the Hina stereotypes than the others (Misty or even Iris and/or Serena, and only the first was definitely not one) were not effectively Claudia, Laura and Paula to Ash's Gaston (and at least those three were just side characters, not the main protagonist). That being said, I wouldn't necessarily take XY059's title without any grains of salt, as the titles have misled us before (don't forget, Date with Delcatty's Japanese title implied that Misty basically was going to nearly get herself killed, when that wasn't even close to being the case. And Luvdisc is a Most Spendored thing made it seem as though there would be a lot of Orangeshipping in the previews, when most if not all of it were just Daisy's overactive imagination).
And for Famon, give her credit where credit is due. While it may not be fully confirmed yet, Serena is still likely to be actually getting a goal now, which means she won't simply be Ash's fangirl now. And to be honest, May and Dawn seemed more of the Unwanted Harem types, they remind me too much of the girls from Love Hina, and not in a good way (and for the record, the Fiorello Fangirls from Princess vs. Princess are basically the same). Then again, I never saw XY, so what am I to say about it. Maybe she is like that and I haven't a clue since I never actually saw even a small portion of an episode of XY in my life, unlike AG or DP, where I at least saw a snippit, if not a few episodes.